… of anti-viral T cells that show broad cross-reactivity across … /IL2 expansion results in
activation of CD8+ T cells. Washing … -1 vaccine regimens that were designed to elicit HIV-1-specific …

… expanding highly functional virus-specific cytotoxic CD8 + T cells, … of TCR signal alone was
sufficient to drive proliferation of … treatment is that in contrast to broadly antigenic HIV vaccines…

… evidence for antigen-driven clonal expansion in vivo and … T cell responses are broad and
heterogeneous (38, 39), we … To study HIV-1–specific cells, we used overlapping Gag peptides, …

… status and function of HIV-specific CD8 + T cells after long-term ART … CD8 + T cells with
high expansion (P<0·0008) and cytotoxic capacity (P=0·02) after in vitro recall, albeit at low cell …

… CD8+ T cell expansion is a common feature of HIV-1 infection… of functional markers in T VM
cells and total CD8+ T cells (Fig… , which enables a broad TCR repertoire and strong immune …

… Latently infected cells can persist through clonal expansion … with a therapeutic vaccine to
strengthen HIV-1-specific T cell … , for example given the far broader effects of TLR8 agonists on …

… , broadly cross-reactive T cell receptors and epitope targeting, enhanced expansion and
antiviral … with a therapeutic vaccine plus PD-1 blockade demonstrated improved and sustained …

… It can induce effective HIV-1-specific immunity to control … regions containing a wide range
of critical T- and B-cell epitopes of … -1 genome can activate Cytotoxic T Lymphocytes (CTLs) in …

… are children, and a protective vaccine or cure is needed to end … potential to develop breadth
as broadly reactive nAbs (bnAbs) … Robust HIV-1-specific CD4 and CD8 T cells were recently …

… such as the TCR sequencing-based assays become broadly … Although HIV-1-specific T-cell
responses were demonstrated … of virus-specific T cells after vaccination requires some time …